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Journal of Cell Science

Sphingomyelin metabolism

RESEARCH ARTICLE

Acylpeptide hydrolase is a novel regulator of KRAS plasma membrane localization and function
Lingxiao Tan, Kwang-Jin Cho, Walaa E. Kattan, Christian M. Garrido, Yong Zhou, Pratik Neupane, Robert J. Capon, John F. Hancock

Journal of Cell Science 2019 132: jcs232132 doi: 10.1242/jcs.232132 Published 31 July 2019

Summary: APEH is a novel regulator of the plasma membrane localization and function of KRAS. Therefore, APEH is a potential drug target for KRAS-dependent human cancers.