splicing
- Role for the splicing factor TCERG1 in Cajal body integrity and snRNP assembly
Highlighted Article: The results suggest a new role for TCERG1 in the formation of Cajal bodies and the biogenesis of snRNPs, which may have a functional consequence for pre-mRNA processing.
- β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment
Highlighted Article: β1 integrin cytoplasmic splicing allows muscle cells to switch from a signaling to an anchoring and signaling-deficient phenotype through interaction with intracellular isoforms of adapter protein talin.
- Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay
Highlighted Article: Upon treatment with splicing inhibitors, unspliced transcripts are exported to the cytoplasm by a mechanism dependent on ALYREF, and are degraded by an EJC-independent NMD pathway.
- RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish
Summary: The zebrafish splicing regulator rbfox1 is necessary for tightly regulated splicing and unconstrained cardiac function, making it an interesting candidate for targeting during human cardiomyopathy.