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splicing

  • RESEARCH ARTICLE
    ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing
    Matías Capella, Lucía Martín Caballero, Boris Pfander, Sigurd Braun, Stefan Jentsch
    Journal of Cell Science 2020 133: jcs250688 doi: 10.1242/jcs.250688 Published 21 December 2020

    Highlighted Article: Heh1-S, the inner nuclear membrane protein resulting from Hub1-mediated splicing of HEH1 pre-mRNA, contributes to nuclear envelope maintenance by preventing excessive recruitment of the ESCRT adaptor Chm7.

  • SHORT REPORT
    Cdc48 regulates intranuclear quality control sequestration of the Hsh155 splicing factor in budding yeast
    Veena Mathew, Arun Kumar, Yangyang K. Jiang, Kyra West, Annie S. Tam, Peter C. Stirling
    Journal of Cell Science 2020 133: jcs252551 doi: 10.1242/jcs.252551 Published 3 December 2020

    Summary: We report the localization and function of the Cdc48 chaperone at intranuclear protein quality control sites in yeast, where it regulates the stability of the Hsh155 splicing factor.

  • RESEARCH ARTICLE
    Role for the splicing factor TCERG1 in Cajal body integrity and snRNP assembly
    Cristina Moreno-Castro, Silvia Prieto-Sánchez, Noemí Sánchez-Hernández, Cristina Hernández-Munain, Carlos Suñé
    Journal of Cell Science 2019 132: jcs232728 doi: 10.1242/jcs.232728 Published 14 November 2019

    Highlighted Article: The results suggest a new role for TCERG1 in the formation of Cajal bodies and the biogenesis of snRNPs, which may have a functional consequence for pre-mRNA processing.

  • RESEARCH ARTICLE
    β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment
    Martinho Soto-Ribeiro, Birgit Kastberger, Michael Bachmann, Latifeh Azizi, Kenza Fouad, Marie-Claude Jacquier, David Boettiger, Daniel Bouvard, Martin Bastmeyer, Vesa P. Hytönen, Bernhard Wehrle-Haller
    Journal of Cell Science 2019 132: jcs224493 doi: 10.1242/jcs.224493 Published 25 April 2019

    Highlighted Article: β1 integrin cytoplasmic splicing allows muscle cells to switch from a signaling to an anchoring and signaling-deficient phenotype through interaction with intracellular isoforms of adapter protein talin.

  • RESEARCH ARTICLE
    Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay
    Teresa Carvalho, Sandra Martins, José Rino, Sérgio Marinho, Maria Carmo-Fonseca
    Journal of Cell Science 2017 130: 1519-1531; doi: 10.1242/jcs.202200

    Highlighted Article: Upon treatment with splicing inhibitors, unspliced transcripts are exported to the cytoplasm by a mechanism dependent on ALYREF, and are degraded by an EJC-independent NMD pathway.

  • RESEARCH ARTICLE
    RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish
    Karen S. Frese, Benjamin Meder, Andreas Keller, Steffen Just, Jan Haas, Britta Vogel, Simon Fischer, Christina Backes, Mark Matzas, Doreen Köhler, Vladimir Benes, Hugo A. Katus, Wolfgang Rottbauer
    Journal of Cell Science 2015 128: 3030-3040; doi: 10.1242/jcs.166850

    Summary: The zebrafish splicing regulator rbfox1 is necessary for tightly regulated splicing and unconstrained cardiac function, making it an interesting candidate for targeting during human cardiomyopathy.

  • ARTICLES
    The influence of 5′ and 3′ end structures on pre-mRNA metabolism
    Joe D. Lewis, Samuel I. Gunderson, Iain W. Mattaj
    Journal of Cell Science 1995 1995: 13-19; doi: 10.1242/jcs.1995.Supplement_19.2

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