TGF-β1
- The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix
Highlighted Article: The presence of the ED-A splice domain enhances the ability of fibronectin to bind latent pro-fibrotic TGF-β1 and thus supports activation of myofibroblasts, which are main drivers of fibrosis.
- Eukaryotic initiation factor 6 modulates myofibroblast differentiation at transforming growth factor-β1 transcription level via H2A.Z occupancy and Sp1 recruitment
Highlighted Article: Eukaryotic initiation factor 6 (eIF6) acts to facilitate Sp1 recruitment to the TGF-β1 promoter through H2A.Z depletion and thus results in increased TGF-β1 transcription, which contributes to myofibroblast differentiation.