Tissue-type plasminogen activator
- Tissue-type plasminogen activator regulates p35-mediated Cdk5 activation in the postsynaptic terminal
Highlighted Article: Here, we show that tissue-type plasminogen activator (tPA) regulates the synaptic expression of p35, and that tPA-induced p35-mediated Cdk5 activation preserves the structure and regulates the receptor composition of the postsynaptic density.
- PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology
Summary: PAI1 inhibits the effects of tissue-type plasminogen activator on cell signaling and physiology mediated by the NMDA receptor. The mechanism of PAI1 activity involves targeting of tPA to the endocytic receptor LRP1.
- The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration
Summary: The NMDA receptor and LRP1 function as co-receptors in Schwann cells, activating cell signaling in response to protein ligands and promoting cell survival and migration.