TORC1
- The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy
Summary: In fission yeast, sexual differentiation is important for survival in environmental changes. We found that Pef1 regulates initiation of sexual differentiation through control of the TORC1 pathway and autophagy.
- Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure
Highlighted Article: A regulatory circuit maintaining intracellular amino acid homeostasis is revealed by studies of yeast growing under high hydrostatic pressure, with a critical role identified for the EGOC–Pib2–TORC1 complex.
- Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling
Summary: ATP and AMP import from external environments modifies growth control in yeast and man.
- Ivy1 is a negative regulator of Gtr-dependent TORC1 activation
Summary: The I-BAR domain-containing protein Ivy1 colocalizes with the EGO complex components Gtr1 and Gtr2 and regulates their activation.
- Lipid droplet consumption is functionally coupled to vacuole homeostasis independent of lipophagy
Highlighted Article: A genome-wide screen in budding yeast reveals that the functional status of vacuoles is relayed to lipid droplets to regulate their efficient utilization, independently of lipophagy.
- Pib2 and the EGO complex are both required for activation of TORC1
Summary: Pib2 and the EGO complex function in the same molecular pathway that leads to the activation of TORC1, a key regulator of cell growth.
- Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1
Summary: In Drosophila and humans, the Mitf transcription factors directly control genes for all v-ATPase subunits, and together with the v-ATPase and TORC1, serve as a dynamic modulator of metabolism.
- The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis
Summary: The I-BAR protein Ivy1 is a new effector of the yeast GTPase Ypt7, which localizes to membrane intrusions and affects the homeostasis of vacuole membranes.
- SEA you later alli-GATOR – a dynamic regulator of the TORC1 stress response pathway
Summary: The multiprotein SEA/GATOR complex is a major upstream regulator of TORC1. This Commentary describes its structural and functional features, and provides an overview of the consequences of its deregulation in cancer.