Transcription factor
- Repetitive switching between DNA-binding modes enables target finding by the glucocorticoid receptor
Summary: Analysis of the intranuclear mobility pattern of the glucocorticoid receptor by using FRAP and single-molecule microscopy (SMM) shows that the receptor is in a ‘repetitive switching’ mode most of the time.
- Reversing thyroid-hormone-mediated repression of a HSV-1 promoter via computationally guided mutagenesis
Summary: Thyroid hormone and its receptor mediate downregulation of HSV-1 thymidine kinase, which is reversed after a computationally guided point mutation disrupts the receptor binding element in neuron-like cell culture.
- Human satellite-III non-coding RNAs modulate heat-shock-induced transcriptional repression
Highlighted Article: The satellite-III non-coding RNAs, expressed only during heat shock in human cells, recruit transcription factors to their nuclear foci, contributing to heat-shock-induced transcriptional repression.
- DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C
Summary: The transcription factor HOXD10 regulates induction of immediate early transcription factors in lymphatic endothelial cells stimulated with the growth factor VEGF-C, and regulates lymphatic endothelial permeability.
- ATF6a, a Runx2-activable transcription factor, is a new regulator of chondrocyte hypertrophy
Summary: ATF6a, a target of the Runx2 and Sox6 transcription factors, positively regulates hypertrophic chondrocyte differentiation and endochondral bone formation by acting as a coactivator of Runx2.
- Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization
Highlighted Article: Luman, an ER-resident transcription factor, regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and transportation during osteoclastogenesis.