Translation
- Translation initiation in cancer at a glance
Summary: The regulation of protein synthesis is altered in many cancers. This article discusses the role of translation initiation in cancer, including recent advances detailing new targets and therapeutic opportunities.
- Ribosome-associated quality control of membrane proteins at the endoplasmic reticulum
Summary: In this review, we describe how errors in membrane protein biogenesis can trigger co-translational degradation that employs machinery of the ribosome-associated quality control pathway.
- The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation
Summary: A fluorescent reporter mouse for visualising F-actin structure and dynamics in live cells also reports T cell activation through a translationallly controlled mechanism.
- RACK1 evolved species-specific multifunctionality in translational control through sequence plasticity within a loop domain
Highlighted Article: Sequence divergence within a poorly understood loop domain of RACK1 functions to control two distinct aspects of translation in different species.
- New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules
Highlighted Article: Novel functions for the de-ubiquitylating enzyme OTUD4 in RNA binding, stress granule formation and neuronal RNA transport granules are presented.
- Upf1 regulates neurite outgrowth and branching by transcriptional and post-transcriptional modulation of Arc
Highlighted Article: Upf1-mediated inhibition of Arc gene expression may contribute to rapid and selective Arc induction in response to vigorous neuronal activity.
- Chronic starvation induces noncanonical pro-death stress granules
Summary: This work characterizes the mechanisms of formation of a novel type of stress granule that is induced in response to long-term starvation and, unlike previously described stress granules, functions in a pro-death capacity.
- Regulation of global translation during the cell cycle
Summary: Using novel approaches we find no major variations in global translation rates through the cell cycle. We also present insights into the role of phosphorylation of eukaryotic initiation factor-2α (eIF2α).
- Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxing Dictyostelium
Summary: The relay of cAMP signals is essential for streaming during Dictyostelium chemotaxis. We report the dynamic enrichment and translation of the mRNA encoding adenylyl cyclase A at the back of cells during this process.
- In situ imaging of mitochondrial translation shows weak correlation with nucleoid DNA intensity and no suppression during mitosis
Highlighted Article: Imaging de novo mitochondrial protein synthesis with a novel fluorescence method shows the translational output throughout the cell and reveals a low correlation with mitochondrion genome copy number.