tyrosine phosphorylation
- STIM1 phosphorylation at Y316 modulates its interaction with SARAF and the activation of SOCE and ICRAC
Summary: STIM1 Y316 phosphorylation results in SARAF dissociation from STIM1, facilitating its activation and interaction with Orai1, then leading to SOCE activation.
- ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility
Summary: ARHGAP42 is activated by Src-mediated Tyr-376 phosphorylation to inhibit RhoA, and promote focal adhesion dynamics and cell motility.
- Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2
Summary: Reactive oxygen species cause two opposite and transient Tyr23-based modifications of annexin A2; its dephosphorylation in the nucleus and phosphorylation at the cell cortex, resulting in release of the protein in exosomes.
- Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission
Summary: Src-mediated phosphorylation on Y100 and Y1065 is a prerequisite for vinculin activation, and controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.