VEGF
- Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier
Summary: Rap1 has been defined as an adhesion-promoting molecule but Rap1B is shown to promote adherens junction disassembly, whereas Rap1A is required for junction maintenance; both isoforms promote junction re-formation following injury.
- VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis
Highlighted Article: VEGFR2 internalises constitutively through clathrin-mediated endocytosis, whereas VEGF induces a new internalisation itinerary for VEGFR2 through macropinocytosis, which is essential for its signalling.
- Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing during angiogenesis
Summary: Activator of G-protein signaling 8 (AGS8) regulates the angiogenic events in endothelial cells by influencing the intracellular distribution of VEGFR-2. A new signal input to angiogenesis by AGS8 is suggested.
- RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells
Highlighted Article: RhoC maintains vascular homeostasis in endothelial cells yet is dispensable for vascular development. Inhibition of RhoC represents an attractive therapeutic approach to prevent cancer metastasis.