YAP
- Real-time imaging of integrin β4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing
Summary: Crispr/Cas9 technology was used to tag an allele of the β4 integrin; reporter cells harboring this allele are useful for obtaining new insight into integrin β4 dynamics during cell migration.
- VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle
Summary: VGLL3 interacts with TEAD transcription factors to direct expression of crucial muscle regulatory genes and contribute to the control of skeletal myogenesis.
- Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis
Summary: This study reveals a functional consequence of intratumor heterogeneity in YAP expression, and suggests that tumorigenesis benefits from competitive interactions between heterogeneous tumor cells.
- Enigma proteins regulate YAP mechanotransduction
Summary: The Enigma family proteins (PDLIM5/7) link YAP with F-actin stress fibers to participate in integrin-mediated mechanotransduction.
- Micropatterning as a tool to identify regulatory triggers and kinetics of actin-mediated endothelial mechanosensing
Summary: A specifically tailored set of micropatterns is used as a cell biological tool to study the regulation of mechanosensitive transcription factors in an angiogenesis model.
- Tension-dependent regulation of mammalian Hippo signaling through LIMD1
Highlighted Article: The mechanism through which YAP activity is regulated by tension at adherens junctions is demonstrated, which helps explain why cell proliferation is inhibited by high cell density and why Rho activity suppresses Hippo signaling.